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Madagascar is an island nation off the southeastern coast of Africa. Grace Cahill had a Madrigal base there.
Grace Cahill used this as her new base other than Attleboro, to keep her daughter (Hope Cahill) safe. The Clue ingriedient Copper is hidden there.
The base been visited by Dan and Amy in the end of The Viper's Nest.
Lucian agent Irina Spasky was banned from Madagascar when she was 19 for unknown reasons.
The Vespers also have a stronghold in Madagascar, underneath the Namorona River, to spy on the Cahills.