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London has historically been dominated by the Lucian branch of the Cahill family. Branch founder Luke Cahill left for London after the Cahill fire and became an advisor for the English royal family. Many members of the branch have resided in London, such as Isaac Newton, Winston Churchill, and many members of the British royal family, including Queen Elizabeth I, Queen Victoria, and Queen Elizabeth II. More recently, London has been the home of the Kabra family, a highly influential Lucian family whose mansion is considered a Lucian stronghold. Another Lucian stronghold, the Tower of London, hides the Clue Salt.
Another branch, the Ekaterina branch, has a stronghold of their own in London, at the British Museum. Ekat agent Victor Wood was born and studied in London. The Tomas branch also selected London to host the Summer Olympics in 1908, 1948, and 2012, establishing temporary strongholds in the city for Clue hunting or other branch activity. Erasmus Yilmaz's dying words also hint at the existence of a Madrigal safe house in the city.
Guardian Jane Sperling lived in London during World War II, working for the War Department. J. Rutherford Pierce also had an office for Founders Media in London, where, at one point, he poisoned several of his agents with Americandy.