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Cartagena is a port city on the northern coast of Colombia. During the height of the Spanish Empire, the city was used as the main port for Spain's empire in the Western Hemisphere.

The Vespers established a stronghold in the city, AWW Cartagena, at the site of one of the operations of Vesper agent Isabel Kabra's charity, AidWorksWonders. The stronghold served as the Vespers' weapons arsenal.

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